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Durability of immune responses after boosting in Ad26.COV2.S-primed healthcare workers.
Sablerolles, Roos S G; Rietdijk, Wim J R; Goorhuis, Abraham; Postma, Douwe F; Visser, Leo G; Schmitz, Katharina S; Geers, Daryl; Bogers, Susanne; van Haren, Eva; Koopmans, Marion P G; Dalm, Virgil A S H; Kootstra, Neeltje A; Huckriede, Anke L W; Akkerman, Renate; Beukema, Martin; Lafeber, Melvin; van Baarle, Debbie; de Vries, Rory D; van der Kuy, P Hugo M; GeurtsvanKessel, Corine H.
Clin Infect Dis ; 2022 Jun 20.
Article in English | MEDLINE | ID: covidwho-2235112

ABSTRACT

The emergence of SARS-CoV-2 variants raised questions regarding the durability of immune responses after homologous or heterologous booster vaccination after Ad26.COV2.S priming. We found that SARS-CoV-2-specific binding antibodies, neutralizing antibodies and T-cells are detectable 5 months after boosting, although waning of antibodies and limited cross-reactivity with Omicron BA.1 was observed.

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